AANAT Polyclonal Antibody

Rs. 16,500.00
SKU E-AB-10969

Overview

Synonyms AA-NAT,Aanat,Aralkylamine N-acetyltransferase,Arylalkylamine N acetyltransferase,Serotonin acetylase,Serotonin N-acetyltransferase,SNAT,SNAT
Swissprot Q16613
Source Rabbit
Reactivity Human,Mouse,Rat
Immunogen Recombinant protein of human AANAT
Application IHC,ELISA
Recommended dilution IHC 1:50-1:200
Concentration 0.6mg/mL
Clonality Polyclonal

Properties

Cellular localization  
Tissue specificity  
Isotype IgG
Purification Affinity purification
Conjugation Unconjugated
Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
Storage buffer PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Background The protein encoded by this gene belongs to the acetyltransferase superfamily. It is the penultimate enzyme in melatonin synthesis and controls the night/day rhythm in melatonin production in the vertebrate pineal gland. Melatonin is essential for the function of the circadian clock that influences activity and sleep. This enzyme is regulated by cAMP-dependent phosphorylation that promotes its interaction with 14-3-3 proteins and thus protects the enzyme against proteasomal degradation. This gene may contribute to numerous genetic diseases such as delayed sleep phase syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. 

 

You recently viewed

Clear recently viewed
Print Friendly and PDF