AATF Polyclonal Antibody

Rs. 16,500.00
SKU E-AB-30907

Overview

Synonyms AATF,AATF,Apoptosis antagonizing transcription factor ,Apoptosis-antagonizing transcription factor,BFR2,CHE 1,CHE1,DED,Protein AATF,Rb binding protein Che 1,Rb-binding protein Che-1
Swissprot Q9NY61
Source Rabbit
Reactivity Human,Mouse,Rat
Immunogen Synthesized peptide derived from the N-terminal region of human Che-1
Application WB,IHC-p,ELISA
Recommended dilution WB 1:500-1:2000, IHC 1:100-1:300, ELISA 1:10000
Concentration 1mg/mL
Clonality Polyclonal

Properties

Cellular localization  
Tissue specificity  
Isotype IgG
Purification Affinity purification
Conjugation Unconjugated
Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
Storage buffer PBS with 0.02% sodium azide,0.5% BSA and 50% glycerol pH 7.4.
Background May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for this phenomenon has not been described to date.

 

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