ACO1 Polyclonal Antibody

Rs. 16,500.00
SKU E-AB-16129

Overview

Synonyms ACO 1,ACO1,ACOC,Aconitase 1 soluble,Aconitase,Aconitase1,Aconitate hydratase,ACONS,Citrate hydro lyase,Citrate hydro-lyase,Cytoplasmic aconitate hydratase,Ferritin repressor protein,IRE BP 1,IRE-BP 1,IREB 1,IREB1,IREBP,IREBP1,Iron regulatory protein 1,Iron responsive element binding protein 1,Iron-responsive element-binding protein 1,IRP 1,IRP1,OTTHUMP00000045233
Swissprot P21399
Source Rabbit
Reactivity Human,Mouse,Rat
Immunogen Synthetic peptide of human ACO1
Application WB,ELISA
Recommended dilution WB 1:1000-1:5000
Concentration 0.2mg/mL
Clonality Polyclonal

Properties

Cellular localization  
Tissue specificity  
Isotype IgG
Purification Affinity purification
Conjugation Unconjugated
Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
Storage buffer PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Background Aconitase 1, also known as iron regulatory element binding protein 1 (IREB1), is a cytosolic protein which binds to iron-responsive elements (IREs). IREs are stem-loop structures found in the 5' UTR of ferritin mRNA, and in the 3' UTR of transferrin receptor mRNA. The iron-induced binding to the IRE results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degrading transferrin receptor mRNA. Thus, IREB1 plays a central role in cellular iron homeostasis. It was also shown to have aconitase activity, and hence grouped with the aconitase family of enzymes.

 

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