ACTN4Polyclonal Antibody

Rs. 16,500.00
SKU E-AB-40184

Overview

Synonyms actinin 4,Actinin alpha 4,actinin4,ACTN 4,ACTN4,ACTN4,Alpha-actinin-4,DKFZp686K23158,F actin cross linking protein,F-actin cross-linking protein,Focal segmental glomerulosclerosis 1,FSGS 1,FSGS,FSGS1,Non muscle alpha actinin 4,Non-muscle alpha-actinin 4
Swissprot O43707
Source Rabbit
Reactivity Human,Mouse
Immunogen Recombinant Human Alpha-actinin-4 protein
Application WB
Recommended dilution WB 1:500-1:2000
Concentration 2mg/mL
Clonality Polyclonal

Properties

Cellular localization  
Tissue specificity  
Isotype IgG
Purification Affinity purification
Conjugation Unconjugated
Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
Storage buffer PBS with 0.05% Proclin300, 50% glycerol, pH7.3.
Background Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, alpha actinin isoform which is concentrated in the cytoplasm, and thought to be involved in metastatic processes.

 

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