ACY1 Polyclonal Antibody

Rs. 21,832.00
SKU E-AB-64650

Overview

Synonyms ACY 1,ACY-1,Acy1,ACY1,ACY1D,ACYLASE,Acylase I,Aminoacylase-1,EC 3.5.1.14,epididymis secretory protein Li 5,HEL-S-5,N acyl L amino acid amidohydrolase,N-acyl-L-amino-acid amidohydrolase,OTTHUMP00000212459,OTTHUMP00000212462,OTTHUMP00000212463,OTTHUMP00000212464,OTTHUMP00000212465
Swissprot Q03154
Source Rabbit
Reactivity Human,Mouse,Rat
Immunogen Recombinant protein of human ACY1
Application WB,IHC
Recommended dilution WB 1:500 - 1:2000 IHC 1:50 - 1:200
Concentration 1mg/ml
Clonality Polyclonal

Properties

Cellular localization  
Tissue specificity  
Isotype IgG
Purification Affinity purification
Conjugation Unconjugated
Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
Storage buffer Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Background This gene encodes a cytosolic, homodimeric, zinc-binding enzyme that catalyzes the hydrolysis of acylated L-amino acids to L-amino acids and an acyl group, and has been postulated to function in the catabolism and salvage of acylated amino acids. This gene is located on chromosome 3p21.1, a region reduced to homozygosity in small-cell lung cancer (SCLC), and its expression has been reported to be reduced or undetectable in SCLC cell lines and tumors. The amino acid sequence of human aminoacylase-1 is highly homologous to the porcine counterpart, and this enzyme is the first member of a new family of zinc-binding enzymes. Mutations in this gene cause aminoacylase-1 deficiency, a metabolic disorder characterized by central nervous system defects and increased urinary excretion of N-acetylated amino acids. Alternative splicing of this gene results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream ABHD14A (abhydrolase domain containing 14A) gene, as represented in GeneID:100526760. A related pseudogene has been identified on chromosome 18.

 

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