ADORA2A Polyclonal Antibody

Rs. 21,832.00
SKU E-AB-60357

Overview

Synonyms A2AAR,A2aR,AA2AR,ADENO,Adenosine A2 receptor,Adenosine A2a receptor,Adenosine receptor A2a,Adenosine receptor subtype A2a,ADORA 2,ADORA2,ADORA2A,hA2aR,RDC 8,RDC8
Swissprot P29274
Source Rabbit
Reactivity Human,Mouse,Rat
Immunogen A synthetic peptide of human ADORA2A
Application WB
Recommended dilution WB 1:500 - 1:1000
Concentration 1mg/ml
Clonality Polyclonal

Properties

Cellular localization  
Tissue specificity  
Isotype IgG
Purification Affinity purification
Conjugation Unconjugated
Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
Storage buffer Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Background This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) superfamily, which is subdivided into classes and subtypes. The receptors are seven-pass transmembrane proteins that respond to extracellular cues and activate intracellular signal transduction pathways. This protein, an adenosine receptor of A2A subtype, uses adenosine as the preferred endogenous agonist and preferentially interacts with the G(s) and G(olf) family of G proteins to increase intracellular cAMP levels. It plays an important role in many biological functions, such as cardiac rhythm and circulation, cerebral and renal blood flow, immune function, pain regulation, and sleep. It has been implicated in pathophysiological conditions such as inflammatory diseases and neurodegenerative disorders. Alternative splicing results in multiple transcript variants. A read-through transcript composed of the upstream SPECC1L (sperm antigen with calponin homology and coiled-coil domains 1-like) and ADORA2A (adenosine A2a receptor) gene sequence has been identified, but it is thought to be non-coding.

 

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