ALAD Polyclonal Antibody

Rs. 21,832.00
SKU E-AB-64148

Overview

Synonyms ALAD,ALADH,ALADR,Aminolevulinate dehydratase ,Aminolevulinate, delta, dehydratase,Delta aminolevulinic acid dehydratase ,Delta-aminolevulinic acid dehydratase,HEM2,Lv,MGC5057,OTTMUSP00000009376,OTTMUSP00000009377,PBGS,Porphobilinogen synthase,RP11-10I9.1,RP24-189G18.9
Swissprot P13716
Source Rabbit
Reactivity Human,Mouse
Immunogen Recombinant protein of human ALAD
Application WB
Recommended dilution WB 1:500 - 1:2000
Concentration 1mg/ml
Clonality Polyclonal

Properties

Cellular localization  
Tissue specificity  
Isotype IgG
Purification Affinity purification
Conjugation Unconjugated
Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
Storage buffer Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Background The ALAD enzyme is composed of 8 identical subunits and catalyzes the condensation of 2 molecules of delta-aminolevulinate to form porphobilinogen (a precursor of heme, cytochromes and other hemoproteins). ALAD catalyzes the second step in the porphyrin and heme biosynthetic pathway; zinc is essential for enzymatic activity. ALAD enzymatic activity is inhibited by lead and a defect in the ALAD structural gene can cause increased sensitivity to lead poisoning and acute hepatic porphyria. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms.

 

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