ALKBH2 Polyclonal Antibody

Rs. 16,500.00
SKU E-AB-10700

Overview

Synonyms 2OG Fe(II) oxy DC1,9530023G02,ABH 2,ABH2,alkB alkylation repair homolog 2,ALKB2,ALKBH2 alkB,ALKBH2,Alkylated DNA repair protein alkB homolog,Alkylated DNA repair protein alkB homolog 2,Alkylation repair homolog 2,Alpha ketoglutarate dependent dioxygenase alkB homolog 2,Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2,AU016977,DNA oxidative demethylase ALKBH2,EC 1.14.11.,FLJ99103,hABH2,mABH2,MGC90512,Oxy DC1
Swissprot Q6NS38
Source Rabbit
Reactivity Human,Mouse
Immunogen Recombinant protein of human ALKBH2
Application WB,ELISA
Recommended dilution WB 1:500-1:2000
Concentration 0.3mg/mL
Clonality Polyclonal

Properties

Cellular localization  
Tissue specificity  
Isotype IgG
Purification Affinity purification
Conjugation Unconjugated
Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
Storage buffer PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Background The Escherichia coli AlkB protein protects against the cytotoxicity of methylating agents by repair of the specific DNA lesions generated in single-stranded DNA. ALKBH2 and ALKBH3 are E. coli AlkB homologs that catalyze the removal of 1-methyladenine and 3-methylcytosine. Dioxygenase that repairs alkylated DNA and RNA containing 1-methyladenine and 3-methylcytosine by oxidative demethylation. Can also repair alkylated DNA containing 1-ethenoadenine (in vitro). Has strong preference for double-stranded DNA. Has low efficiency with single-stranded substrates. Requires molecular oxygen, alpha-ketoglutarate and iron.

 

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