ALX4 Polyclonal Antibody

Rs. 16,500.00
SKU E-AB-12269

Overview

Synonyms Alx4,ALX4,Aristaless like homeobox 4,CRS5,FND2,FPP,homeobox protein aristaless like 4,Homeobox protein aristaless-like 4,homeodomain transcription factor ALX4,KIAA1788,PFM1,PFM2
Swissprot Q9H161
Source Rabbit
Reactivity Human,Mouse
Immunogen Synthetic peptide of human ALX4
Application IHC,ELISA
Recommended dilution IHC 1:25-1:100
Concentration 0.5mg/mL
Clonality Polyclonal

Properties

Cellular localization  
Tissue specificity  
Isotype IgG
Purification Affinity purification
Conjugation Unconjugated
Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
Storage buffer PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Background This gene encodes a paired-like homeodomain transcription factor expressed in the mesenchyme of developing bones, limbs, hair, teeth, and mammary tissue. Mutations in this gene cause parietal foramina 2 (PFM2); an autosomal dominant disease characterized by deficient ossification of the parietal bones. Mutations in this gene also cause a form of frontonasal dysplasia with alopecia and hypogonadism; suggesting a role for this gene in craniofacial development, mesenchymal-epithelial communication, and hair follicle development. Deletion of a segment of chromosome 11 containing this gene, del(11)(p11p12), causes Potocki-Shaffer syndrome (PSS); a syndrome characterized by craniofacial anomalies, mental retardation, multiple exostoses, and genital abnormalities in males. In mouse, this gene has been shown to use dual translation initiation sites located 16 codons apart.

 

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