Anti-53BP1 antibody

Rs. 50,211.00
SKU stj91390

General Information

Product name Anti-53BP1 antibody
Short Description
Description Rabbit polyclonal to 53BP1.
Applications WB,ELISA
Dilution range WB 1:500-1:2000ELISA 1:10000
Protein Name Anti-53BP1 antibody
Immunogen Synthesized peptide derived from human 53BP1 around the non-phosphorylation site of S29.
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity Human,Mouse
Conjugation Unconjugated
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Target

Gene ID
Gene Symbol
Molecular Weight 170 kDa
Database Links
Alternative Names TP53-binding protein 1 antibody
p53-binding protein 1 antibody
pTP53BP1 antibody
Function Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis . Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 . In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites . Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites . Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs . Participates to the repair and the orientation of the broken DNA ends during CSR . In contrast, it is not required for classic NHEJ and V(D)J recombination . Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 .
Cellular Localization Nucleus Chromosome Chromosome, centromere, kinetochore. Localizes to the nucleus in absence of DNA damage . Following DNA damage, recruited to sites of DNA damage, such as double stand breaks (DSBs): recognizes and binds histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites . Associated with kinetochores during mitosis .
Tissue Specificity
Swiss-Prot Key

 

You recently viewed

Clear recently viewed
Print Friendly and PDF