Anti-A1Up antibody

Rs. 50,211.00
SKU stj91401

General Information

Product name Anti-A1Up antibody
Short Description
Description Rabbit polyclonal to A1Up.
Applications WB,IHC,ELISA
Dilution range WB 1:500-1:2000IHC 1:100-1:300ELISA 1:40000
Protein Name Anti-A1Up antibody
Immunogen Synthesized peptide derived from human A1Up
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity Human,Mouse
Conjugation Unconjugated
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Target

Gene ID
Gene Symbol
Molecular Weight 54 kDa
Database Links
Alternative Names Ubiquilin-4 antibody
Ataxin-1 interacting ubiquitin-like protein antibody
Ataxin-1 ubiquitin-like-interacting protein A1U antibody
Connexin43-interacting protein of 75 kDa antibody
CIP75 antibody
C1orf6 antibody
CIP75 antibody
UBIN antibody
Function Plays a role in the regulation of protein degradation via the ubiquitin-proteasome system (UPS). Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by interacting (via ubiquitin-like domain) with the subunits of the proteasome (Ref. 6). Plays a role in the regulation of the proteasomal degradation of non-ubiquitinated GJA1 . Acts as an adapter protein that recruits UBQLN1 to the autophagy machinery. Mediates the association of UBQLN1 with autophagosomes and the autophagy-related protein LC3 (MAP1LC3A/B/C) and may assist in the maturation of autophagosomes to autolysosomes by mediating autophagosome-lysosome fusion .
Cellular Localization Nucleus Cytoplasm Endoplasmic reticulum Cytoplasm, perinuclear region Cytoplasmic vesicle, autophagosome. Colocalizes with the proteasome, both in nucleus and cytoplasm.
Tissue Specificity Highly expressed in pancreas, kidney, skeletal muscle, heart and throughout the brain, and at lower levels in placenta, lung and liver.
Swiss-Prot Key

 

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