Anti-A2M Antibody

Rs. 45,619.00
SKU stj22453

General Information

Product name Anti-A2M Antibody
Short Description Rabbit polyclonal to A2M
Description Alpha-2-macroglobulin is a protease inhibitor and cytokine transporter. It inhibits many proteases, including trypsin, thrombin and collagenase. A2M is implicated in Alzheimer disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits.
Applications WB,IF
Dilution range WB 1:500 - 1:2000
IF 1:50 - 1:200
Protein Name Anti-A2M Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1155-1474 of human A2M (NP_000005.2).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 163.3 kDa
Database Links
Alternative Names A2MAlpha-2-macroglobulin antibodyAlpha-2-M antibodyC3 and PZP-like alpha-2-macroglobulin domain-containing protein 5A2M antibodyCPAMD5 antibodyFWP007
Function Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism, This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases, When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase, The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced), Following cleavage in the bait region, a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase
Cellular Localization Secreted
Tissue Specificity Secreted in plasma.
Swiss-Prot Key

 

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