Anti-AANAT Antibody

Rs. 61,689.00
SKU stj113429

General Information

Product name Anti-AANAT Antibody
Short Description Rabbit polyclonal to AANAT
Description The protein encoded by this gene belongs to the acetyltransferase superfamily. It is the penultimate enzyme in melatonin synthesis and controls the night/day rhythm in melatonin production in the vertebrate pineal gland. Melatonin is essential for the function of the circadian clock that influences activity and sleep. This enzyme is regulated by cAMP-dependent phosphorylation that promotes its interaction with 14-3-3 proteins and thus protects the enzyme against proteasomal degradation. This gene may contribute to numerous genetic diseases such as delayed sleep phase syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Applications WB
Dilution range WB 1:500 - 1:1000
Protein Name Serotonin N-acetyltransferaseSerotonin acetylase
Immunogen A synthetic peptide of human AANAT
Storage Instruction Store at 4℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity Human
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 23.3 kDa
Database Links
Alternative Names AANATSerotonin N-acetyltransferase antibodySerotonin acetylaseAANAT antibodySNAT
Function Controls the night/day rhythm of melatonin production in the pineal gland, Catalyzes the N-acetylation of serotonin into N-acetylserotonin, the penultimate step in the synthesis of melatonin.
Cellular Localization Cytoplasm
Tissue Specificity Highly expressed in pineal gland and at lower levels in the retina, weak expression in several brain regions and in the pituitary gland.
Swiss-Prot Key

 

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