Anti-ABCA4 Antibody

Rs. 57,098.00
SKU stj71853

General Information

Product name Anti-ABCA4 Antibody
Short Description Goat polyclonal to ABCA4
Description
Applications ELISA
Dilution range
Protein Name Anti-ABCA4 Antibody
Immunogen internal region
Storage Instruction
Type of Usage For Research Use Only (RUO).

Product Properties

Host Goat
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Isotype
Formulation Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.

Target

Gene ID
Gene Symbol
Molecular Weight 255.9 kDa
Database Links
Alternative Names ABCA4Retinal-specific ATP-binding cassette transporter antibodyATP-binding cassette sub-family A member 4 antibodyRIM ABC transporter antibodyRIM protein antibodyRmP antibodyStargardt disease proteinABCA4 antibodyABCR
Function In the visual cycle, acts as an inward-directed retinoid flipase, retinoid substrates imported by ABCA4 from the extracellular or intradiscal (rod) membrane surfaces to the cytoplasmic membrane surface are all-trans-retinaldehyde (ATR) and N-retinyl-phosphatidyl-ethanolamine (NR-PE), Once transported to the cytoplasmic surface, ATR is reduced to vitamin A by trans-retinol dehydrogenase (tRDH) and then transferred to the retinal pigment epithelium (RPE) where it is converted to 11-cis-retinal, May play a role in photoresponse, removing ATR/NR-PE from the extracellular photoreceptor surfaces during bleach recovery,
Cellular Localization Membrane,
Tissue Specificity Retinal-specific, seems to be exclusively found in the rims of rod photoreceptor cells
Swiss-Prot Key

 

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