Anti-ABCB1 Antibody

Rs. 45,619.00
SKU stj29844

General Information

Product name Anti-ABCB1 Antibody
Short Description Rabbit polyclonal to ABCB1
Description The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. Mutations in this gene are associated with colchicine resistance and Inflammatory bowel disease 13. Alternative splicing and the use of alternative promoters results in multiple transcript variants.
Applications WB
Dilution range WB 1:500 - 1:2000
Protein Name Anti-ABCB1 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 630-710 of human ABCB1 (NP_000918.2).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 141.5 kDa
Database Links
Alternative Names ABCB1Multidrug resistance protein 1 ABCB1 antibodyMDR1 antibodyPGY1
Function Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells
Cellular Localization Cell membrane
Tissue Specificity Expressed in liver, kidney, small intestine and brain
Swiss-Prot Key

 

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