Anti-ABCG2 Antibody

Rs. 45,619.00
SKU stj27931

General Information

Product name Anti-ABCG2 Antibody
Short Description Rabbit polyclonal to ABCG2
Description The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as a breast cancer resistance protein, this protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. It likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. Significant expression of this protein has been observed in the placenta, which may suggest a potential role for this molecule in placenta tissue. Multiple transcript variants encoding different isoforms have been found for this gene.
Applications WB
Dilution range WB 1:500 - 1:2000
Protein Name Anti-ABCG2 Antibody
Immunogen A synthetic peptide of human ABCG2
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 72.3 kDa
Database Links
Alternative Names ABCG2ATP-binding cassette sub-family G member 2 antibodyBreast cancer resistance protein antibodyCDw338 antibodyMitoxantrone resistance-associated protein antibodyPlacenta-specific ATP-binding cassette transporter antibodyUrate exporter antibodyCD antigen CD338ABCG2 antibodyABCP antibodyBCRP antibodyBCRP1 antibodyMXR
Function High-capacity urate exporter functioning in both renal and extrarenal urate excretion, Plays a role in porphyrin homeostasis as it is able to mediates the export of protoporhyrin IX (PPIX) both from mitochondria to cytosol and from cytosol to extracellular space, and cellular export of hemin, and heme, Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from the brain, Appears to play a major role in the multidrug resistance phenotype of several cancer cell lines, Implicated in the efflux of numerous drugs and xenobiotics: mitoxantrone, the photosensitizer pheophorbide, camptothecin, methotrexate, azidothymidine (AZT), and the anthracyclines daunorubicin and doxorubicin.
Cellular Localization Cell membrane
Tissue Specificity Highly expressed in placenta, low expression in small intestine, liver and colon.
Swiss-Prot Key

 

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