Anti-ACE Antibody

Rs. 45,619.00
SKU stj29978

General Information

Product name Anti-ACE Antibody
Short Description Rabbit polyclonal to ACE
Description This gene encodes an enzyme involved in catalyzing the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. This enzyme plays a key role in the renin-angiotensin system. Many studies have associated the presence or absence of a 287 bp Alu repeat element in this gene with the levels of circulating enzyme or cardiovascular pathophysiologies. Multiple alternatively spliced transcript variants encoding different isoforms have been identified, and two most abundant spliced variants encode the somatic form and the testicular form, respectively, that are equally active.
Applications WB,IHC
Dilution range WB 1:500 - 1:2000
IHC 1:50 - 1:100
Protein Name Anti-ACE Antibody
Immunogen A synthetic peptide of human ACE
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 149.7 kDa
Database Links
Alternative Names ACEAngiotensin-converting enzyme antibodyACEACE antibodyDCP antibodyDCP1
Function Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin, Also able to inactivate bradykinin, a potent vasodilator, Has also a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety
Cellular Localization Angiotensin-converting enzyme, soluble form: Secreted
Tissue Specificity Ubiquitously expressed, with highest levels in lung, kidney, heart, gastrointestinal system and prostate, isoform testis-specific is expressed in spermatocytes and adult testis.
Swiss-Prot Key

 

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