Anti-ACKR3 Antibody

Rs. 68,577.00
SKU stj73457

General Information

Product name Anti-ACKR3 Antibody
Short Description Goat polyclonal to ACKR3
Description
Applications ELISA, WB
Dilution range
Protein Name Anti-ACKR3 Antibody
Immunogen C Terminus
Storage Instruction
Type of Usage For Research Use Only (RUO).

Product Properties

Host Goat
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Isotype
Formulation Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.

Target

Gene ID
Gene Symbol
Molecular Weight 41.5 kDa
Database Links
Alternative Names ACKR3Atypical chemokine receptor 3 antibodyC-X-C chemokine receptor type 7 antibodyCXC-R7 antibodyCXCR-7 antibodyChemokine orphan receptor 1 antibodyG-protein coupled receptor 159 antibodyG-protein coupled receptor RDC1 homolog antibodyRDC-1ACKR3 antibodyCMKOR1 antibodyCXCR7 antibodyGPR159 antibodyRDC1
Function Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis, Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor, Acts as a receptor for chemokines CXCL11 and CXCL12/SDF1, Chemokine binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization and activation of MAPK signaling pathway, Required for regulation of CXCR4 protein levels in migrating interneurons, thereby adapting their chemokine responsiveness, In glioma cells, transduces signals via MEK/ERK pathway, mediating resistance to apoptosis, Promotes cell growth and survival, Not involved in cell migration, adhesion or proliferation of normal hematopoietic progenitors but activated by CXCL11 in malignant hemapoietic cells, leading to phosphorylation of ERK1/2 (MAPK3/MAPK1) and enhanced cell adhesion and migration, Plays a regulatory role in CXCR4-mediated activation of cell surface integrins by CXCL12, Required for heart valve development, Acts as coreceptor with CXCR4 for a restricted number of HIV isolates,
Cellular Localization Cell membrane
Tissue Specificity Expressed in monocytes, basophils, b-cells, umbilical vein endothelial cells (huvec) and b-lymphoblastoid cells, lower expression detected in cd4+ t-lymphocytes and natural killer cells, in the brain, detected in endothelial cells and capillaries, and in mature neurons of the frontal cortex and hippocampus, expressed in tubular formation in the kidney, highly expressed in astroglial tumor endothelial, microglial and glioma cells, expressed at low levels in normal cd34+ progenitor cells, but at very high levels in several myeloid malignant cell lines, expressed in breast carcinomas but not in normal breast tissue (at protein level),
Swiss-Prot Key

 

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