Anti-ACVR1B Antibody

Rs. 45,619.00
SKU stj27406

General Information

Product name Anti-ACVR1B Antibody
Short Description Rabbit polyclonal to ACVR1B
Description This gene encodes an activin A type IB receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I and two type II receptors. This protein is a type I receptor which is essential for signaling. Mutations in this gene are associated with pituitary tumors. Alternate splicing results in multiple transcript variants.
Applications WB
Dilution range WB 1:500 - 1:2000
Protein Name Anti-ACVR1B Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 24-126 of human ACVR1B (NP_004293.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 56.8 kDa
Database Links
Alternative Names ACVR1BActivin receptor type-1B ACVR1B antibodyACVRLK4 antibodyALK4
Function Transmembrane serine/threonine kinase activin type-1 receptor forming an activin receptor complex with activin receptor type-2 (ACVR2A or ACVR2B), Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating a many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis, Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary, Within the receptor complex, type-2 receptors (ACVR2A and/or ACVR2B) act as a primary activin receptors whereas the type-1 receptors like ACVR1B act as downstream transducers of activin signals, Activin binds to type-2 receptor at the plasma membrane and activates its serine-threonine kinase, The activated receptor type-2 then phosphorylates and activates the type-1 receptor such as ACVR1B, Once activated, the type-1 receptor binds and phosphorylates the SMAD proteins SMAD2 and SMAD3, on serine residues of the C-terminal tail, Soon after their association with the activin receptor and subsequent phosphorylation, SMAD2 and SMAD3 are released into the cytoplasm where they interact with the common partner SMAD4, This SMAD complex translocates into the nucleus where it mediates activin-induced transcription, Inhibitory SMAD7, which is recruited to ACVR1B through FKBP1A, can prevent the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal, Activin signal transduction is also antagonized by the binding to the receptor of inhibin-B via the IGSF1 inhibin coreceptor, ACVR1B also phosphorylates TDP2.
Cellular Localization Cell membrane
Tissue Specificity Expressed in many tissues, most strongly in kidney, pancreas, brain, lung, and liver
Swiss-Prot Key

 

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