Anti-ACVR2A Antibody

Rs. 45,619.00
SKU stj22506

General Information

Product name Anti-ACVR2A Antibody
Short Description Rabbit polyclonal to ACVR2A
Description This gene encodes a receptor that mediates the functions of activins, which are members of the transforming growth factor-beta (TGF-beta) superfamily involved in diverse biological processes. The encoded protein is a transmembrane serine-threonine kinase receptor which mediates signaling by forming heterodimeric complexes with various combinations of type I and type II receptors and ligands in a cell-specific manner. The encoded type II receptor is primarily involved in ligand-binding and includes an extracellular ligand-binding domain, a transmembrane domain and a cytoplasmic serine-threonine kinase domain. This gene may be associated with susceptibility to preeclampsia, a pregnancy-related disease which can result in maternal and fetal morbidity and mortality. Alternative splicing results in multiple transcript variants of this gene.
Applications WB,IHC,IF
Dilution range WB 1:500 - 1:2000
IHC 1:100 - 1:200
IF 1:50 - 1:200
Protein Name Anti-ACVR2A Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 20-140 of human ACVR2A (NP_001607.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 57.8 kDa
Database Links
Alternative Names ACVR2AActivin receptor type-2A ACVR2A antibodyACVR2
Function On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases, Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, Receptor for activin A, activin B and inhibin A, Mediates induction of adipogenesis by GDF6 (By similarity).
Cellular Localization Membrane
Tissue Specificity
Swiss-Prot Key

 

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