Anti-AGER Antibody

Rs. 45,619.00
SKU stj22543

General Information

Product name Anti-AGER Antibody
Short Description Rabbit polyclonal to AGER
Description The advanced glycosylation end product (AGE) receptor encoded by this gene is a member of the immunoglobulin superfamily of cell surface receptors. It is a multiligand receptor, and besides AGE, interacts with other molecules implicated in homeostasis, development, and inflammation, and certain diseases, such as diabetes and Alzheimer's disease. Many alternatively spliced transcript variants encoding different isoforms, as well as non-protein-coding variants, have been described for this gene (PMID:18089847).
Applications WB
Dilution range WB 1:500 - 1:2000
Protein Name Anti-AGER Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 30-330 of human AGER (NP_001127.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 42.8 kDa
Database Links
Alternative Names AGERAdvanced glycosylation end product-specific receptor antibodyReceptor for advanced glycosylation end productsAGER antibodyRAGE
Function Mediates interactions of advanced glycosylation end products (AGE), These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes, Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes, AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes, Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators, Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling (By similarity), Receptor for amyloid beta peptide, Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons, ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space, Can also bind oligonucleotides.
Cellular Localization Cell membrane
Tissue Specificity Endothelial cells
Swiss-Prot Key

 

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