Anti-AGO1 Antibody

Rs. 45,619.00
SKU stj27818

General Information

Product name Anti-AGO1 Antibody
Short Description Rabbit polyclonal to AGO1
Description This gene encodes a member of the argonaute family of proteins, which associate with small RNAs and have important roles in RNA interference (RNAi) and RNA silencing. This protein binds to microRNAs (miRNAs) or small interfering RNAs (siRNAs) and represses translation of mRNAs that are complementary to them. It is also involved in transcriptional gene silencing (TGS) of promoter regions that are complementary to bound short antigene RNAs (agRNAs), as well as in the degradation of miRNA-bound mRNA targets. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A recent study showed this gene to be an authentic stop codon readthrough target, and that its mRNA could give rise to an additional C-terminally extended isoform by use of an alternative in-frame translation termination codon.
Applications WB
Dilution range WB 1:500 - 1:1000
Protein Name Anti-AGO1 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human AGO1 (NP_036331.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 97.2 kDa
Database Links
Alternative Names AGO1Protein argonaute-1 antibodyArgonaute1 antibodyhAgo1 antibodyArgonaute RISC catalytic component 1 antibodyEukaryotic translation initiation factor 2C 1 antibodyeIF-2C 1 antibodyeIF2C 1 antibodyPutative RNA-binding protein Q99AGO1 antibodyEIF2C1
Function Required for RNA-mediated gene silencing (RNAi), Binds to short RNAs such as microRNAs (miRNAs) or short interfering RNAs (siRNAs), and represses the translation of mRNAs which are complementary to them, Lacks endonuclease activity and does not appear to cleave target mRNAs, Also required for transcriptional gene silencing (TGS) of promoter regions which are complementary to bound short antigene RNAs (agRNAs).
Cellular Localization Cytoplasm, P-body
Tissue Specificity
Swiss-Prot Key

 

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