Anti-AGR2 Antibody

Rs. 45,619.00
SKU stj29144

General Information

Product name Anti-AGR2 Antibody
Short Description Rabbit polyclonal to AGR2
Description This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, a catalytically active thioredoxin domain, and a C-terminal ER-retention sequence. This protein plays a role in cell migration, cellular transformation and metastasis and is as a p53 inhibitor. As an ER-localized molecular chaperone, it plays a role in the folding, trafficking, and assembly of cysteine-rich transmembrane receptors and the cysteine-rich intestinal gylcoprotein mucin. This gene has been implicated in inflammatory bowel disease and cancer progression.
Applications WB
Dilution range WB 1:500 - 1:2000
Protein Name Anti-AGR2 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 21-175 of human AGR2 (NP_006399.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 20 kDa
Database Links
Alternative Names AGR2Anterior gradient protein 2 homolog antibodyAG-2 antibodyhAG-2 antibodyHPC8 antibodySecreted cement gland protein XAG-2 homologAGR2 antibodyAG2 antibodyUNQ515/PRO1030
Function Required for MUC2 post-transcriptional synthesis and secretion, May play a role in the production of mucus by intestinal cells (By similarity), Proto-oncogene that may play a role in cell migration, cell differentiation and cell growth, Promotes cell adhesion.
Cellular Localization Secreted
Tissue Specificity Expressed strongly in trachea, lung, stomach, colon, prostate and small intestine, expressed weakly in pituitary gland, salivary gland, mammary gland, bladder, appendix, ovary, fetal lung, uterus, pancreas, kidney, fetal kidney, testis, placenta, thyroid gland and in estrogen receptor (er)-positive breast cancer cell lines.
Swiss-Prot Key

 

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