Anti-AIFM1 Antibody

Rs. 68,577.00
SKU stj73128

General Information

Product name Anti-AIFM1 Antibody
Short Description Goat polyclonal to AIFM1
Description
Applications ELISA, IF, WB
Dilution range
Protein Name Anti-AIFM1 Antibody
Immunogen C Terminus
Storage Instruction
Type of Usage For Research Use Only (RUO).

Product Properties

Host Goat
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Isotype
Formulation Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.

Target

Gene ID
Gene Symbol
Molecular Weight 66.9 kDa
Database Links
Alternative Names AIFM1Apoptosis-inducing factor 1 antibodymitochondrial AIFM1 antibodyAIF antibodyPDCD8
Function Functions both as NADH oxidoreductase and as regulator of apoptosis, In response to apoptotic stimuli, it is released from the mitochondrion intermembrane space into the cytosol and to the nucleus, where it functions as a proapoptotic factor in a caspase-independent pathway, In contrast, functions as an antiapoptotic factor in normal mitochondria via its NADH oxidoreductase activity, The soluble form (AIFsol) found in the nucleus induces 'parthanatos' i,e, caspase-independent fragmentation of chromosomal DNA, Interacts with EIF3G,and thereby inhibits the EIF3 machinery and protein synthesis, and activates casapse-7 to amplify apoptosis, Plays a critical role in caspase-independent, pyknotic cell death in hydrogen peroxide-exposed cells, Binds to DNA in a sequence-independent manner,
Cellular Localization Mitochondrion intermembrane space, Mitochondrion inner membrane, Cytoplasm, Nucleus, Cytoplasm, perinuclear region, Mitochondrion intermembrane space
Tissue Specificity Detected in muscle and skin fibroblasts (at protein level), isoform 5 is frequently down-regulated in human cancers,
Swiss-Prot Key

 

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