Anti-AIM2 Antibody

Rs. 45,619.00
SKU stj22558

General Information

Product name Anti-AIM2 Antibody
Short Description Rabbit polyclonal to AIM2
Description AIM2 is a member of the IFI20X /IFI16 family. It plays a putative role in tumorigenic reversion and may control cell proliferation. Interferon-gamma induces expression of AIM2.
Applications WB
Dilution range WB 1:500 - 1:2000
Protein Name Anti-AIM2 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human AIM2 (NP_004824.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 39 kDa
Database Links
Alternative Names AIM2Interferon-inducible protein AIM2 antibodyAbsent in melanoma 2AIM2
Function Involved in innate immune response by recognizing cytosolic double-stranded DNA and inducing caspase-1-activating inflammasome formation in macrophages, Upon binding to DNA is thought to undergo oligomerization and to associate with PYCARD initiating the recruitment of caspase-1 precusrsor and processing of interleukin-1 beta and interleukin-18, Detects cytosolic dsDNA of viral and bacterial origin in a non-sequence-specific manner, Can also trigger PYCARD-dependent, caspase-1-independent cell death that involves caspase-8 (By similarity), Tumor suppressor which may act by repressing NF-kappa-B transcriptional activity.
Cellular Localization Nucleus, Cytoplasm.
Tissue Specificity Expressed in spleen, small intestine, peripheral blood leukocytes, and testis.
Swiss-Prot Key

 

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