Anti-AIM2 Antibody

Rs. 68,577.00
SKU stj72168

General Information

Product name Anti-AIM2 Antibody
Short Description Goat polyclonal to AIM2
Description
Applications ELISA, WB
Dilution range
Protein Name Anti-AIM2 Antibody
Immunogen internal region
Storage Instruction
Type of Usage For Research Use Only (RUO).

Product Properties

Host Goat
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Isotype
Formulation Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.

Target

Gene ID
Gene Symbol
Molecular Weight 39 kDa
Database Links
Alternative Names AIM2Interferon-inducible protein AIM2 antibodyAbsent in melanoma 2AIM2
Function Involved in innate immune response by recognizing cytosolic double-stranded DNA and inducing caspase-1-activating inflammasome formation in macrophages, Upon binding to DNA is thought to undergo oligomerization and to associate with PYCARD initiating the recruitment of caspase-1 precusrsor and processing of interleukin-1 beta and interleukin-18, Detects cytosolic dsDNA of viral and bacterial origin in a non-sequence-specific manner, Can also trigger PYCARD-dependent, caspase-1-independent cell death that involves caspase-8 (By similarity), Tumor suppressor which may act by repressing NF-kappa-B transcriptional activity,
Cellular Localization Nucleus, Cytoplasm,
Tissue Specificity Expressed in spleen, small intestine, peripheral blood leukocytes, and testis,
Swiss-Prot Key

 

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