Anti-AIRE Antibody

Rs. 45,619.00
SKU stj22559

General Information

Product name Anti-AIRE Antibody
Short Description Rabbit polyclonal to AIRE
Description This gene encodes a transcriptional regulator that forms nuclear bodies and interacts with the transcriptional coactivator CREB binding protein. The encoded protein plays an important role in immunity by regulating the expression of autoantigens and negative selection of autoreactive T-cells in the thymus. Mutations in this gene cause the rare autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy with candidiasis and ectodermal dystrophy (APECED).
Applications WB,IF
Dilution range WB 1:500 - 1:2000
IF 1:50 - 1:200
Protein Name Anti-AIRE Antibody
Immunogen A synthetic peptide of human AIRE
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 57.7 kDa
Database Links
Alternative Names AIREAutoimmune regulator antibodyAutoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein antibodyAPECED proteinAIRE antibodyAPECED
Function Transcription factor playing an essential role to promote self-tolerance in the thymus by regulating the expression of a wide array of self-antigens that have the commonality of being tissue-restricted in their expression pattern in the periphery, called tissue restricted antigens (TRA).
Cellular Localization Nucleus.
Tissue Specificity Widely expressed, expressed at higher level in thymus (medullary epithelial cells and monocyte-dendritic cells), pancreas, adrenal cortex and testis, expressed at lower level in the spleen, fetal liver and lymph nodes, in secondary lymphoid organs, expressed in a discrete population of bone marrow-derived toleregenic antigen presenting cells (apcs) called extrathymic aire expressing cells (etac)(at protein level) , isoform 2 and isoform 3 seem to be less frequently expressed than isoform 1, if at all.
Swiss-Prot Key

 

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