Anti-AIRE (isoform 1) Antibody

Rs. 68,577.00
SKU stj70934

General Information

Product name Anti-AIRE (isoform 1) Antibody
Short Description Goat polyclonal to AIRE (isoform 1)
Description
Applications ELISA, WB, IHC
Dilution range
Protein Name Anti-AIRE (isoform 1) Antibody
Immunogen internal region
Storage Instruction
Type of Usage For Research Use Only (RUO).

Product Properties

Host Goat
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Isotype
Formulation Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.

Target

Gene ID
Gene Symbol
Molecular Weight 57.7 kDa
Database Links
Alternative Names AIREAutoimmune regulator antibodyAutoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein antibodyAPECED proteinAIRE antibodyAPECED
Function Transcription factor playing an essential role to promote self-tolerance in the thymus by regulating the expression of a wide array of self-antigens that have the commonality of being tissue-restricted in their expression pattern in the periphery, called tissue restricted antigens (TRA) ,
Cellular Localization Nucleus,
Tissue Specificity Widely expressed, expressed at higher level in thymus (medullary epithelial cells and monocyte-dendritic cells), pancreas, adrenal cortex and testis, expressed at lower level in the spleen, fetal liver and lymph nodes, in secondary lymphoid organs, expressed in a discrete population of bone marrow-derived toleregenic antigen presenting cells (apcs) called extrathymic aire expressing cells (etac)(at protein level) , isoform 2 and isoform 3 seem to be less frequently expressed than isoform 1, if at all,
Swiss-Prot Key

 

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