Anti-AK2 Antibody

Rs. 61,689.00
SKU stj22561

General Information

Product name Anti-AK2 Antibody
Short Description Rabbit polyclonal to AK2
Description Adenylate kinases are involved in regulating the adenine nucleotide composition within a cell by catalyzing the reversible transfer of phosphate groups among adenine nucleotides. Three isozymes of adenylate kinase, namely 1, 2, and 3, have been identified in vertebrates; this gene encodes isozyme 2. Expression of these isozymes is tissue-specific and developmentally regulated. Isozyme 2 is localized in the mitochondrial intermembrane space and may play a role in apoptosis. Mutations in this gene are the cause of reticular dysgenesis. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 1 and 2.
Applications WB,IHC
Dilution range WB 1:500 - 1:2000
IHC 1:50 - 1:200
Protein Name Anti-AK2 Antibody
Immunogen A synthetic peptide of human AK2
Storage Instruction Store at 4℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 26.5 kDa
Database Links
Alternative Names AK2Adenylate kinase 2 antibodymitochondrial antibodyAK 2AK2 antibodyADK2
Function Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP, Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism, Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways, Plays a key role in hematopoiesis.
Cellular Localization Mitochondrion intermembrane space
Tissue Specificity Present in most tissues, present at high level in heart, liver and kidney, and at low level in brain, skeletal muscle and skin, present in thrombocytes but not in erythrocytes, which lack mitochondria, present in all nucleated cell populations from blood, while ak1 is mostly absent, in spleen and lymph nodes, mononuclear cells lack ak1, whereas ak2 is readily detectable, these results indicate that leukocytes may be susceptible to defects caused by the lack of ak2, as they do not express ak1 in sufficient amounts to compensate for the ak2 functional deficits (at protein level).
Swiss-Prot Key

 

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