Anti-AKR1C3 Antibody

Rs. 45,619.00
SKU stj115529

General Information

Product name Anti-AKR1C3 Antibody
Short Description Rabbit polyclonal to AKR1C3
Description This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ), and the oxidation of 9alpha,11beta-PGF2 to PGD2. It may play an important role in the pathogenesis of allergic diseases such as asthma, and may also have a role in controlling cell growth and/or differentiation. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. Three transcript variants encoding different isoforms have been found for this gene.
Applications WB,IHC,IF
Dilution range WB 1:500 - 1:2000
IHC 1:50 - 1:200
IF 1:50 - 1:200
Protein Name Aldo-keto reductase family 1 member C3
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-323 of human AKR1C3 (NP_003730.4).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity Human,Rat
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 36.9 kDa
Database Links
Alternative Names AKR1C3Aldo-keto reductase family 1 member C3 AKR1C3 antibodyDDH1 antibodyHSD17B5 antibodyKIAA0119 antibodyPGFS
Function Catalyzes the conversion of aldehydes and ketones to alcohols, Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta-PGF2 to PGD2, Functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD, Can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites, Preferentially transforms androstenedione (4-dione) to testosterone
Cellular Localization Cytoplasm
Tissue Specificity Expressed in many tissues including adrenal gland, brain, kidney, liver, lung, mammary gland, placenta, small intestine, colon, spleen, prostate and testis, the dominant hsd in prostate and mammary gland, in the prostate, higher levels in epithelial cells than in stromal cells, in the brain, expressed in medulla, spinal cord, frontotemporal lobes, thalamus, subthalamic nuclei and amygdala, weaker expression in the hippocampus, substantia nigra and caudate.
Swiss-Prot Key

 

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