Anti-AKR1C4 Antibody

Rs. 45,619.00
SKU stj29566

General Information

Product name Anti-AKR1C4 Antibody
Short Description Rabbit polyclonal to AKR1C4
Description This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the bioreduction of chlordecone, a toxic organochlorine pesticide, to chlordecone alcohol in liver. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14.
Applications WB
Dilution range WB 1:500 - 1:2000
Protein Name Anti-AKR1C4 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-323 of human AKR1C4 (NP_001809.3).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 37.1 kDa
Database Links
Alternative Names AKR1C4Aldo-keto reductase family 1 member C4 AKR1C4 antibodyCHDR
Function Catalyzes the transformation of the potent androgen dihydrotestosterone (DHT) into the less active form, 5-alpha-androstan-3-alpha,17-beta-diol (3-alpha-diol), Also has some 20-alpha-hydroxysteroid dehydrogenase activity, The biotransformation of the pesticide chlordecone (kepone) to its corresponding alcohol leads to increased biliary excretion of the pesticide and concomitant reduction of its neurotoxicity since bile is the major excretory route
Cellular Localization Cytoplasm
Tissue Specificity Liver specific.
Swiss-Prot Key

 

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