Anti-AKT3 Antibody

Rs. 68,577.00
SKU stj70624

General Information

Product name Anti-AKT3 Antibody
Short Description Goat polyclonal to AKT3
Description
Applications ELISA, WB, IHC
Dilution range
Protein Name Anti-AKT3 Antibody
Immunogen internal region
Storage Instruction
Type of Usage For Research Use Only (RUO).

Product Properties

Host Goat
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Isotype
Formulation Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.

Target

Gene ID
Gene Symbol
Molecular Weight 55.8 kDa
Database Links
Alternative Names AKT3RAC-gamma serine/threonine-protein kinase AKT3 antibodyPKBG
Function AKT3 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis, This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates, Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported, AKT3 is the least studied AKT isoform, It plays an important role in brain development and is crucial for the viability of malignant glioma cells, AKT3 isoform may also be the key molecule in up-regulation and down-regulation of MMP13 via IL13, Required for the coordination of mitochondrial biogenesis with growth factor-induced increases in cellular energy demands, Down-regulation by RNA interference reduces the expression of the phosphorylated form of BAD, resulting in the induction of caspase-dependent apoptosis,
Cellular Localization Nucleus,
Tissue Specificity In adult tissues, it is highly expressed in brain, lung and kidney, but weakly in heart, testis and liver, in fetal tissues, it is highly expressed in heart, liver and brain and not at all in kidney
Swiss-Prot Key

 

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