Anti-ALDH4A1 Antibody

Rs. 45,619.00
SKU stj22583

General Information

Product name Anti-ALDH4A1 Antibody
Short Description Rabbit polyclonal to ALDH4A1
Description This protein belongs to the aldehyde dehydrogenase family of proteins. This enzyme is a mitochondrial matrix NAD-dependent dehydrogenase which catalyzes the second step of the proline degradation pathway, converting pyrroline-5-carboxylate to glutamate. Deficiency of this enzyme is associated with type II hyperprolinemia, an autosomal recessive disorder characterized by accumulation of delta-1-pyrroline-5-carboxylate (P5C) and proline. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.
Applications WB,IF
Dilution range WB 1:500 - 1:2000
IF 1:50 - 1:200
Protein Name Anti-ALDH4A1 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 354-563 of human ALDH4A1 (NP_003739.2).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 61.7 kDa
Database Links
Alternative Names ALDH4A1Delta-1-pyrroline-5-carboxylate dehydrogenase antibodymitochondrial antibodyP5C dehydrogenaseALDH4A1 antibodyALDH4 antibodyP5CDH
Function Irreversible conversion of delta-1-pyrroline-5-carboxylate (P5C), derived either from proline or ornithine, to glutamate, This is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles, The preferred substrate is glutamic gamma-semialdehyde, other substrates include succinic, glutaric and adipic semialdehydes.
Cellular Localization Mitochondrion matrix
Tissue Specificity Highest expression is found in liver followed by skeletal muscle, kidney, heart, brain, placenta, lung and pancreas
Swiss-Prot Key

 

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