Anti-ALOX15B Antibody

Rs. 45,619.00
SKU stj28945

General Information

Product name Anti-ALOX15B Antibody
Short Description Rabbit polyclonal to ALOX15B
Description This gene encodes a member of the lipoxygenase family of structurally related nonheme iron dioxygenases involved in the production of fatty acid hydroperoxides. The encoded protein converts arachidonic acid exclusively to 15S-hydroperoxyeicosatetraenoic acid, while metabolizing linoleic acid less effectively. This gene is located in a cluster of related genes and a pseudogene that spans approximately 100 kilobases on the short arm of chromosome 17. Alternatively spliced transcript variants encoding different isoforms have been described.
Applications WB,IF
Dilution range WB 1:500 - 1:2000
IHC 1:50 - 1:200
IF 1:50 - 1:200
Protein Name Anti-ALOX15B Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human ALOX15B (NP_001132.2).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 75.9 kDa
Database Links
Alternative Names ALOX15BArachidonate 15-lipoxygenase B antibody15-LOX-BALOX15B
Function Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators, Converts arachidonic acid to 15S-hydroperoxyeicosatetraenoic acid/(15S)-HPETE, Also acts on linoleic acid to produce 13-hydroxyoctadecadienoic acid/13-HPODE, Has no detectable 8S-lipoxygenase activity but reacts with (8S)-HPETE to produce (8S,15S)-diHPETE, May regulate progression through the cell cycle and cell proliferation, May also regulate cytokine secretion by macrophages and therefore play a role in the immune response, May also regulate macrophage differentiation into proatherogenic foam cells.
Cellular Localization Nucleus, becomes enriched at membranes upon calcium binding
Tissue Specificity Expressed in hair, prostate, lung, ovary, lymph node, spinal cord and cornea.
Swiss-Prot Key

 

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