Anti-ALS2 Antibody

Rs. 45,619.00
SKU stj116266

General Information

Product name Anti-ALS2 Antibody
Short Description Rabbit polyclonal to ALS2
Description The protein encoded by this gene contains an ATS1/RCC1-like domain, a RhoGEF domain, and a vacuolar protein sorting 9 (VPS9) domain, all of which are guanine-nucleotide exchange factors that activate members of the Ras superfamily of GTPases. The protein functions as a guanine nucleotide exchange factor for the small GTPase RAB5. The protein localizes with RAB5 on early endosomal compartments, and functions as a modulator for endosomal dynamics. Mutations in this gene result in several forms of juvenile lateral sclerosis and infantile-onset ascending spastic paralysis. Multiple transcript variants encoding different isoforms have been found for this gene.
Applications WB,IF
Dilution range WB 1:200 - 1:2000
IF 1:50 - 1:200
Protein Name AlsinAmyotrophic lateral sclerosis 2 chromosomal region candidate gene 6 proteinAmyotrophic lateral sclerosis 2 protein
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human ALS2 (NP_065970.2).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity Human,Mouse
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 183.6 kDa
Database Links
Alternative Names ALS2Alsin antibodyAmyotrophic lateral sclerosis 2 chromosomal region candidate gene 6 protein antibodyAmyotrophic lateral sclerosis 2 proteinALS2 antibodyALS2CR6 antibodyKIAA1563
Function May act as a GTPase regulator, Controls survival and growth of spinal motoneurons (By similarity).
Cellular Localization
Tissue Specificity
Swiss-Prot Key

 

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