Anti-ALYREF Antibody

Rs. 45,619.00
SKU stj27806

General Information

Product name Anti-ALYREF Antibody
Short Description Rabbit polyclonal to ALYREF
Description The protein encoded by this gene is a heat stable, nuclear protein and functions as a molecular chaperone. It is thought to regulate dimerization, DNA binding, and transcriptional activity of basic region-leucine zipper (bZIP) proteins.
Applications WB,IHC
Dilution range WB 1:500 - 1:2000
IHC 1:50 - 1:200
Protein Name Anti-ALYREF Antibody
Immunogen Recombinant protein of human ALYREF
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 26.9 kDa
Database Links
Alternative Names ALYREFTHO complex subunit 4 antibodyTho4 antibodyAlly of AML-1 and LEF-1 antibodyAly/REF export factor antibodyTranscriptional coactivator Aly/REF antibodybZIP-enhancing factor BEFALYREF antibodyALY antibodyBEF antibodyTHOC4
Function Export adapter involved in nuclear export of spliced and unspliced mRNA, Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NFX1 pathway), Component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA, TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm, TREX recruitment occurs via an interaction between ALYREF/THOC4 and the cap-binding protein NCBP1, The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production
Cellular Localization Nucleus.
Tissue Specificity Expressed in a wide variety of cancer types.
Swiss-Prot Key

 

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