Anti-AMFR Antibody

Rs. 45,619.00
SKU stj22602

General Information

Product name Anti-AMFR Antibody
Short Description Rabbit polyclonal to AMFR
Description This locus encodes a glycosylated transmembrane receptor. Its ligand, autocrine motility factor, is a tumor motility-stimulating protein secreted by tumor cells. The encoded receptor is also a member of the E3 ubiquitin ligase family of proteins. It catalyzes ubiquitination and endoplasmic reticulum-associated degradation of specific proteins.
Applications WB
Dilution range WB 1:500 - 1:2000
Protein Name Anti-AMFR Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 384-643 of human AMFR (NP_001135.3).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 73 kDa
Database Links
Alternative Names AMFRE3 ubiquitin-protein ligase AMFR AMFR antibodyRNF45
Function E3 ubiquitin-protein ligase that mediates the polyubiquitination of a number of proteins such as CD3D, CYP3A4, CFTR and APOB for proteasomal degradation, Component of a VCP/p97-AMFR/gp78 complex that participates in the final step of endoplasmic reticulum-associated degradation (ERAD), The VCP/p97-AMFR/gp78 complex is involved in the sterol-accelerated ERAD degradation of HMGCR through binding to the HMGCR-INSIG complex at the ER membrane and initiating ubiquitination of HMGCR, The ubiquitinated HMGCR is then released from the ER by the complex into the cytosol for subsequent destruction, Also regulates ERAD through the ubiquitination of UBL4A a component of the BAG6/BAT3 complex, Also acts as a scaffold protein to assemble a complex that couples ubiquitination, retranslocation and deglycosylation, Mediates tumor invasion and metastasis as a receptor for the GPI/autocrine motility factor.
Cellular Localization Endoplasmic reticulum membrane
Tissue Specificity
Swiss-Prot Key

 

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