Anti-Amyloid beta peptide Antibody

Rs. 68,577.00
SKU stj72677

General Information

Product name Anti-Amyloid beta peptide Antibody
Short Description Goat polyclonal to Amyloid beta peptide (mouse)
Description
Applications ELISA, WB
Dilution range
Protein Name Anti-Amyloid beta peptide Antibody
Immunogen N Terminus
Storage Instruction
Type of Usage For Research Use Only (RUO).

Product Properties

Host Goat
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Isotype
Formulation Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.

Target

Gene ID
Gene Symbol
Molecular Weight 86.7 kDa
Database Links
Alternative Names Anti-Amyloid beta peptide (mouse) Antibody
Function Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis, Interaction between APP molecules on neighboring cells promotes synaptogenesis, Involved in cell mobility and transcription regulation through protein-protein interactions, Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb, Couples to apoptosis-inducing pathways such as those mediated by G(O) and JIP, Inhibits G(o) alpha ATPase activity (By similarity), Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1, May be involved in copper homeostasis/oxidative stress through copper ion reduction, Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I and IV (By similarity), The splice isoforms that contain the BPTI domain possess protease inhibitor activity, Induces a AGER-dependent pathway that involves activation of p38 MAPK, resulting in internalization of amyloid-beta peptide and leading to mitochondrial dysfunction in cultured cortical neurons (By similarity), Provides Cu(2+) ions for GPC1 which are required for release of nitric oxide (NO) and subsequent degradation of the heparan sulfate chains on GPC1,
Cellular Localization Cell membrane, most of the protein is present in intracellular vesicles, During maturation, the immature APP (N-glycosylated in the endoplasmic reticulum) moves to the Golgi complex where complete maturation occurs (O-glycosylated and sulfated), After alpha-secretase cleavage, soluble APP is released into the extracellular space and the C-terminal is internalized to endosomes and lysosomes, Some APP accumulates in secretory transport vesicles leaving the late Golgi compartment and returns to the cell surface, Gamma-CTF(59) peptide is located to both the cytoplasm and nuclei of neurons, It can be translocated to the nucleus through association with APBB1 (Fe65), Amyloid-beta protein 42 associates with FRPL1 at the cell surface and the complex is then rapidly internalized, APP sorts to the basolateral surface in epithelial cells, During neuronal differentiation, the Thr-743 phosphorylated form is located mainly in growth cones, moderately in neurites and sparingly in the cell body, Casein kinase phosphorylation can occur either at the cell surface or within a post-Golgi compartment (By similarity), Associates with GPC1 in perinuclear compartments ,
Tissue Specificity Isoform app770 is expressed in kidney, isoform app751 is widely expressed, isoform app695 is expressed in brain, kidney and liver, isoform app695, isoform app714 and isoform app751 are expressed in several different brain regions including hippocampus, substania nigra pars compacta and cerebellum, in the cerebellum, these isoforms are abundantly expressed in purkinje cells,
Swiss-Prot Key

 

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