Anti-ANGPT1 Antibody

Rs. 68,577.00
SKU stj72337

General Information

Product name Anti-ANGPT1 Antibody
Short Description Goat polyclonal to ANGPT1
Description
Applications ELISA, WB
Dilution range
Protein Name Anti-ANGPT1 Antibody
Immunogen internal region
Storage Instruction
Type of Usage For Research Use Only (RUO).

Product Properties

Host Goat
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Isotype
Formulation Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.

Target

Gene ID
Gene Symbol
Molecular Weight 57.5 kDa
Database Links
Alternative Names ANGPT1Angiopoietin-1 antibodyANG-1ANGPT1 antibodyKIAA0003
Function Binds and activates TEK/TIE2 receptor by inducing its dimerization and tyrosine phosphorylation, Plays an important role in the regulation of angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence, Required for normal angiogenesis and heart development during embryogenesis, After birth, activates or inhibits angiogenesis, depending on the context, Inhibits angiogenesis and promotes vascular stability in quiescent vessels, where endothelial cells have tight contacts, In quiescent vessels, ANGPT1 oligomers recruit TEK to cell-cell contacts, forming complexes with TEK molecules from adjoining cells, and this leads to preferential activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascades, In migrating endothelial cells that lack cell-cell adhesions, ANGT1 recruits TEK to contacts with the extracellular matrix, leading to the formation of focal adhesion complexes, activation of PTK2/FAK and of the downstream kinases MAPK1/ERK2 and MAPK3/ERK1, and ultimately to the stimulation of sprouting angiogenesis, Mediates blood vessel maturation/stability, Implicated in endothelial developmental processes later and distinct from that of VEGF, Appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme,
Cellular Localization Secreted
Tissue Specificity
Swiss-Prot Key

 

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