Anti-ANGPTL4 Antibody

Rs. 45,619.00
SKU stj115386

General Information

Product name Anti-ANGPTL4 Antibody
Short Description Rabbit polyclonal to ANGPTL4
Description This gene encodes a glycosylated, secreted protein containing a C-terminal fibrinogen domain. The encoded protein is induced by peroxisome proliferation activators and functions as a serum hormone that regulates glucose homeostasis, lipid metabolism, and insulin sensitivity. This protein can also act as an apoptosis survival factor for vascular endothelial cells and can prevent metastasis by inhibiting vascular growth and tumor cell invasion. The C-terminal domain may be proteolytically-cleaved from the full-length secreted protein. Decreased expression of this gene has been associated with type 2 diabetes. Alternative splicing results in multiple transcript variants. This gene was previously referred to as ANGPTL2 but has been renamed ANGPTL4.
Applications IF
Dilution range IF 1:50 - 1:200
Protein Name Angiopoietin-related protein 4Angiopoietin-like protein 4Hepatic fibrinogen/angiopoietin-related proteinHFARP
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 26-406 of human ANGPTL4 (NP_647475.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity Human
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 45.2 kDa
Database Links
Alternative Names ANGPTL4Angiopoietin-related protein 4 antibodyAngiopoietin-like protein 4 antibodyHepatic fibrinogen/angiopoietin-related protein antibodyHFARPANGPTL4 antibodyARP4 antibodyHFARP antibodyPGAR antibodyPP1158 antibodyPSEC0166 antibodyUNQ171/PRO197
Function Protein with hypoxia-induced expression in endothelial cells, May act as a regulator of angiogenesis and modulate tumorigenesis, Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage, May exert a protective function on endothelial cells through an endocrine action, It is directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity, In response to hypoxia, the unprocessed form of the protein accumulates in the subendothelial extracellular matrix (ECM), The matrix-associated and immobilized unprocessed form limits the formation of actin stress fibers and focal contacts in the adhering endothelial cells and inhibits their adhesion, It also decreases motility of endothelial cells and inhibits the sprouting and tube formation (By similarity).
Cellular Localization Secreted.
Tissue Specificity Expressed at high levels in the placenta, heart, liver, muscle, pancreas and lung but expressed poorly in the brain and kidney.
Swiss-Prot Key

 

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