Anti-ANPEP Antibody

Rs. 45,619.00
SKU stj27629

General Information

Product name Anti-ANPEP Antibody
Short Description Rabbit polyclonal to ANPEP
Description Aminopeptidase N is located in the small-intestinal and renal microvillar membrane, and also in other plasma membranes. In the small intestine aminopeptidase N plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Its function in proximal tubular epithelial cells and other cell types is less clear. The large extracellular carboxyterminal domain contains a pentapeptide consensus sequence characteristic of members of the zinc-binding metalloproteinase superfamily. Sequence comparisons with known enzymes of this class showed that CD13 and aminopeptidase N are identical. The latter enzyme was thought to be involved in the metabolism of regulatory peptides by diverse cell types, including small intestinal and renal tubular epithelial cells, macrophages, granulocytes, and synaptic membranes from the CNS. Human aminopeptidase N is a receptor for one strain of human coronavirus that is an important cause of upper respiratory tract infections. Defects in this gene appear to be a cause of various types of leukemia or lymphoma.
Applications WB
Dilution range WB 1:500 - 1:2000
Protein Name Anti-ANPEP Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 668-967 of human ANPEP (NP_001141.2).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 109.5 kDa
Database Links
Alternative Names ANPEPAminopeptidase N antibodyAP-N antibodyhAPNANPEP antibodyAPN antibodyCD13 antibodyPEPN
Function Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases, Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines, May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells, May have a role in angiogenesis and promote cholesterol crystallization.
Cellular Localization Cell membrane
Tissue Specificity Expressed in epithelial cells of the kidney, intestine, and respiratory tract
Swiss-Prot Key

 

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