Anti-ANXA7 Antibody

Rs. 45,619.00
SKU stj22622

General Information

Product name Anti-ANXA7 Antibody
Short Description Rabbit polyclonal to ANXA7
Description Annexin VII is a member of the annexin family of calcium-dependent phospholipid binding proteins.The Annexin VII gene contains 14 exons and spans approximately 34 kb of DNA. An alternatively spliced cassette exon results in two mRNA transcripts of 2.0 and 2.4 kb which are predicted to generate two protein isoforms differing in their N-terminal domain. The alternative splicing event is tissue specific and the mRNA containing the cassette exon is prevalent in brain, heart and skeletal muscle. The transcripts also differ in their 3'-non coding regions by the use of two alternative poly(A) signals. Annexin VII encodes a protein with a molecular weight of approximately 51 kDa with a unique, highly hydrophobic N-terminal domain of 167 amino acids and a conserved C-terminal region of 299 amino acids. The latter domain is composed of alternating hydrophobic and hydrophilic segments. Structural analysis of the protein suggests that Annexin VII is a membrane binding protein with diverse properties, including voltage-sensitive calcium channel activity, ion selectivity and membrane fusion.
Applications WB,IF
Dilution range WB 1:200 - 1:2000
IF 1:50 - 1:200
Protein Name Anti-ANXA7 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 237-466 of human ANXA7 (NP_001147.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 52.7 kDa
Database Links
Alternative Names ANXA7Annexin A7 antibodyAnnexin VII antibodyAnnexin-7 antibodySynexinANXA7 antibodyANX7 antibodySNX antibodyOK/SW-cl.95
Function Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis
Cellular Localization
Tissue Specificity Isoform 1 is expressed in brain, heart and skeletal muscle, isoform 2 is more abundant in liver, lung, kidney, spleen, fibroblasts and placenta.
Swiss-Prot Key

 

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