Anti-AP-1 antibody

Rs. 50,211.00
SKU stj91616

General Information

Product name Anti-AP-1 antibody
Short Description Rabbit polyclonal to AP-1.
Description AP-1 is a protein encoded by the JUN gene which is approximately 35,6 kDa. AP-1 is localised to the nucleus. It is involved in activated TLR4 signalling, the IL-2 pathway, toll-like receptor signalling pathways, development HGF signalling pathway and TNFR1 pathway. It interacts directly with specific target DNA sequences to regulate gene expression. It promotes activity of NR5A1 when phosphorylated by HIPK3, leading to increased steroidogenic gene expression upon cAMP signalling pathway stimulation. AP-1 is expressed in the nervous system, pancreas, lung, intestine and muscle. Mutations in the JUN gene may result in brain sarcoma and campylobacteriosis. stj91616 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of AP-1 protein only when phosphorylated at S63.
Applications WB,IHC,IP,ELISA
Dilution range WB 1:500-1:2000IHC 1:100-1:300IP 1:200-500ELISA 1:20000
Protein Name Anti-AP-1 antibody
Immunogen Synthesized peptide derived from human AP-1 around the non-phosphorylation site of T91.
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity Human,Mouse,Rat
Conjugation Unconjugated
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Target

Gene ID
Gene Symbol
Molecular Weight 48 kDa
Database Links
Alternative Names Transcription factor AP-1 antibody
Activator protein 1 antibody
AP1 antibody
Proto-oncogene c-Jun antibody
V-jun avian sarcoma virus 17 oncogene homolog antibody
p39 antibody
Function Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. Involved in activated KRAS-mediated transcriptional activation of USP28 in colorectal cancer (CRC) cells . Binds to the USP28 promoter in colorectal cancer (CRC) cells .
Cellular Localization Nucleus.
Tissue Specificity
Swiss-Prot Key

 

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