Anti-AP2A1 Antibody

Rs. 45,619.00
SKU stj28943

General Information

Product name Anti-AP2A1 Antibody
Short Description Rabbit polyclonal to AP2A1
Description This gene encodes the alpha 1 adaptin subunit of the adaptor protein 2 (AP-2) complex found in clathrin coated vesicles. The AP-2 complex is a heterotetramer consisting of two large adaptins (alpha or beta), a medium adaptin (mu), and a small adaptin (sigma). The complex is part of the protein coat on the cytoplasmic face of coated vesicles which links clathrin to receptors in vesicles. Alternative splicing of this gene results in two transcript variants encoding two different isoforms. A third transcript variant has been described, but its full length nature has not been determined.
Applications WB,IHC
Dilution range WB 1:500 - 1:2000
IHC 1:50 - 1:200
Protein Name Anti-AP2A1 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human AP2A1 (NP_055018.2).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 107.5 kDa
Database Links
Alternative Names AP2A1AP-2 complex subunit alpha-1 antibody100 kDa coated vesicle protein A antibodyAdaptor protein complex AP-2 subunit alpha-1 antibodyAdaptor-related protein complex 2 subunit alpha-1 antibodyAlpha-adaptin A antibodyAlpha1-adaptin antibodyClathrin assembly protein complex 2 alpha-A large chain antibodyPlasma membrane adaptor HA2/AP2 adaptin alpha A subunitAP2A1 antibodyADTAA antibodyCLAPA1
Function Component of the adaptor protein complex 2 (AP-2), Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways, Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation, AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome, The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components, Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation, AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis, AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface, AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules, AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway, The AP-2 alpha subunit binds polyphosphoinositide-containing lipids, positioning AP-2 on the membrane, The AP-2 alpha subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins, The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif (By similarity).
Cellular Localization Cell membrane
Tissue Specificity Isoform a expressed in forebrain, skeletal muscle, spinal cord, cerebellum, salivary gland, heart and colon, isoform b is widely expressed in tissues and also in breast cancer and in prostate carcinoma cells
Swiss-Prot Key

 

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