Anti-AP2A2 Antibody

Rs. 45,619.00
SKU stj115239

General Information

Product name Anti-AP2A2 Antibody
Short Description Rabbit polyclonal to AP2A2
Description The protein encoded by this gene is a subunit of the AP-2 adaptor protein complex, which is involved in linking lipid and protein membrane components with the clathrin lattice. This interaction supports the formation of clathrin-coated vesicles, and the encoded subunit aids in the process by binding polyphosphoinositide-containing lipids in the cell membrane.
Applications WB,IHC
Dilution range WB 1:500 - 1:2000
IHC 1:50 - 1:200
Protein Name AP-2 complex subunit alpha-2100 kDa coated vesicle protein CAdaptor protein complex AP-2 subunit alpha-2Adaptor-related protein complex 2 subunit alpha-2Alpha-adaptin CAlpha2-adaptinClathrin assembly protein complex 2 alpha-C large chainHuntingtin yeast partner JHuntingtin-interacting protein 9HIP-9Huntingtin-interacting protein JPlasma membrane adaptor HA2/AP2 adaptin alpha C subunit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 590-939 of human AP2A2 (NP_036437.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity Human,Mouse
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 104 kDa
Database Links
Alternative Names AP2A2AP-2 complex subunit alpha-2 antibody100 kDa coated vesicle protein C antibodyAdaptor protein complex AP-2 subunit alpha-2 antibodyAdaptor-related protein complex 2 subunit alpha-2 antibodyAlpha-adaptin C antibodyAlpha2-adaptin antibodyClathrin assembly protein complex 2 alpha-C large chain antibodyHuntingtin yeast partner J antibodyHuntingtin-interacting protein 9 antibodyHIP-9 antibodyHuntingtin-interacting protein J antibodyPlasma membrane adaptor HA2/AP2 adaptin alpha C subunitAP2A2 antibodyADTAB antibodyCLAPA2 antibodyHIP9 antibodyHYPJ antibodyKIAA0899
Function Component of the adaptor protein complex 2 (AP-2), Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways, Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation, AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome, The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components, Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation, AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis, AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface, AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules, AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway, The AP-2 alpha subunit binds polyphosphoinositide-containing lipids, positioning AP-2 on the membrane, The AP-2 alpha subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins, The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif (By similarity).
Cellular Localization Cell membrane
Tissue Specificity
Swiss-Prot Key

 

You recently viewed

Clear recently viewed
Print Friendly and PDF