Anti-AP2B1 Antibody

Rs. 45,619.00
SKU stj22627

General Information

Product name Anti-AP2B1 Antibody
Short Description Rabbit polyclonal to AP2B1
Description The protein encoded by this gene is one of two large chain components of the assembly protein complex 2, which serves to link clathrin to receptors in coated vesicles. The encoded protein is found on the cytoplasmic face of coated vesicles in the plasma membrane. Two transcript variants encoding different isoforms have been found for this gene.
Applications WB,IHC
Dilution range WB 1:500 - 1:2000
IHC 1:50 - 1:200
Protein Name Anti-AP2B1 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 752-951 of human AP2B1 (NP_001025177.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 104.6 kDa
Database Links
Alternative Names AP2B1AP-2 complex subunit beta antibodyAP105B antibodyAdaptor protein complex AP-2 subunit beta antibodyAdaptor-related protein complex 2 subunit beta antibodyBeta-2-adaptin antibodyBeta-adaptin antibodyClathrin assembly protein complex 2 beta large chain antibodyPlasma membrane adaptor HA2/AP2 adaptin beta subunitAP2B1 antibodyADTB2 antibodyCLAPB1
Function Component of the adaptor protein complex 2 (AP-2), Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways, Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation, AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome, The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components, Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation, AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis, AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface, AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules, AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway, The AP-2 beta subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins
Cellular Localization Cell membrane.
Tissue Specificity
Swiss-Prot Key

 

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