Anti-AP2M1 Antibody

Rs. 45,619.00
SKU stj22628

General Information

Product name Anti-AP2M1 Antibody
Short Description Rabbit polyclonal to AP2M1
Description This gene encodes a subunit of the heterotetrameric coat assembly protein complex 2 (AP2), which belongs to the adaptor complexes medium subunits family. The encoded protein is required for the activity of a vacuolar ATPase, which is responsible for proton pumping occurring in the acidification of endosomes and lysosomes. The encoded protein may also play an important role in regulating the intracellular trafficking and function of CTLA-4 protein. Three transcript variants encoding different isoforms have been found for this gene.
Applications WB,IHC
Dilution range WB 1:500 - 1:2000
IHC 1:50 - 1:200
Protein Name Anti-AP2M1 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 134-433 of human AP2M1 (NP_001020376.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 49.7 kDa
Database Links
Alternative Names AP2M1AP-2 complex subunit mu antibodyAP-2 mu chain antibodyAdaptin-mu2 antibodyAdaptor protein complex AP-2 subunit mu antibodyAdaptor-related protein complex 2 subunit mu antibodyClathrin assembly protein complex 2 mu medium chain antibodyClathrin coat assembly protein AP50 antibodyClathrin coat-associated protein AP50 antibodyHA2 50 kDa subunit antibodyPlasma membrane adaptor AP-2 50 kDa proteinAP2M1 antibodyCLAPM1 antibodyKIAA0109
Function Component of the adaptor protein complex 2 (AP-2), Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways, Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation, AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome, The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components, Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation, AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis, AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface, AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules, AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway, The AP-2 mu subunit binds to transmembrane cargo proteins
Cellular Localization Cell membrane, Membrane, coated pit
Tissue Specificity
Swiss-Prot Key

 

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