Anti-APBB1 Antibody

Rs. 45,619.00
SKU stj26186

General Information

Product name Anti-APBB1 Antibody
Short Description Rabbit polyclonal to APBB1
Description The protein encoded by this gene is a member of the Fe65 protein family. It is an adaptor protein localized in the nucleus. It interacts with the Alzheimer's disease amyloid precursor protein (APP), transcription factor CP2/LSF/LBP1 and the low-density lipoprotein receptor-related protein. APP functions as a cytosolic anchoring site that can prevent the gene product's nuclear translocation. This encoded protein could play an important role in the pathogenesis of Alzheimer's disease. It is thought to regulate transcription. Also it is observed to block cell cycle progression by downregulating thymidylate synthase expression. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Applications WB,IHC,IF
Dilution range WB 1:500 - 1:2000
IHC 1:50 - 1:200
IF 1:50 - 1:200
Protein Name Anti-APBB1 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 359-708 of human APBB1 (NP_663722.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 77.2 kDa
Database Links
Alternative Names APBB1Amyloid-beta A4 precursor protein-binding family B member 1 antibodyProtein Fe65APBB1 antibodyFE65 antibodyRIR
Function Transcription coregulator that can have both coactivator and corepressor functions, Adapter protein that forms a transcriptionally active complex with the gamma-secretase-derived amyloid precursor protein (APP) intracellular domain, Plays a central role in the response to DNA damage by translocating to the nucleus and inducing apoptosis, May act by specifically recognizing and binding histone H2AX phosphorylated on 'Tyr-142' (H2AXY142ph) at double-strand breaks (DSBs), recruiting other pro-apoptosis factors such as MAPK8/JNK1, Required for histone H4 acetylation at double-strand breaks (DSBs), Its ability to specifically bind modified histones and chromatin modifying enzymes such as KAT5/TIP60, probably explains its transcription activation activity, Function in association with TSHZ3, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4, Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s).
Cellular Localization Cell membrane, Cytoplasm, Nucleus, Cell projection, growth cone, Nucleus speckle.
Tissue Specificity Highly expressed in brain
Swiss-Prot Key

 

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