Anti-APBB1 Antibody

Rs. 68,577.00
SKU stj70979

General Information

Product name Anti-APBB1 Antibody
Short Description Goat polyclonal to APBB1
Description
Applications ELISA, WB
Dilution range
Protein Name Anti-APBB1 Antibody
Immunogen C Terminus
Storage Instruction
Type of Usage For Research Use Only (RUO).

Product Properties

Host Goat
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Isotype
Formulation Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.

Target

Gene ID
Gene Symbol
Molecular Weight 77.2 kDa
Database Links
Alternative Names APBB1Amyloid-beta A4 precursor protein-binding family B member 1 antibodyProtein Fe65APBB1 antibodyFE65 antibodyRIR
Function Transcription coregulator that can have both coactivator and corepressor functions, Adapter protein that forms a transcriptionally active complex with the gamma-secretase-derived amyloid precursor protein (APP) intracellular domain, Plays a central role in the response to DNA damage by translocating to the nucleus and inducing apoptosis, May act by specifically recognizing and binding histone H2AX phosphorylated on 'Tyr-142' (H2AXY142ph) at double-strand breaks (DSBs), recruiting other pro-apoptosis factors such as MAPK8/JNK1, Required for histone H4 acetylation at double-strand breaks (DSBs), Its ability to specifically bind modified histones and chromatin modifying enzymes such as KAT5/TIP60, probably explains its transcription activation activity, Function in association with TSHZ3, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4, Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s),
Cellular Localization Cell membrane, Cytoplasm, Nucleus, Cell projection, growth cone, Nucleus speckle,
Tissue Specificity Highly expressed in brain
Swiss-Prot Key

 

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