Anti-APC antibody

Rs. 57,098.00
SKU stj29775

General Information

Product name Anti-APC antibody
Short Description Rabbit polyclonal to APC
Description This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product.
Applications WB,IHC,ICC,IP
Dilution range WB 1:500 - 1:1000
IHC 1:50 - 1:100
ICC 1:50 - 1:100
IP 1:25 - 1:50
Protein Name Anti-APC antibody
Immunogen A synthetic peptide of human APC
Storage Instruction Store at -20C. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 311.646 kDa
Database Links
Alternative Names Adenomatous polyposis coli protein antibody
Protein APC antibody
Deleted in polyposis 2.5 antibody
DP2.5 antibody
Function Tumor suppressor, Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator, APC activity is correlated with its phosphorylation state, Activates the GEF activity of SPATA13 and ARHGEF4, Plays a role in hepatocyte growth factor (HGF)-induced cell migration, Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells, Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex, It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization,
Cellular Localization Cell junction, adherens junction,
Tissue Specificity Expressed in a variety of tissues: brain, small intestine, colon, thymus, skeletal muscle, heart, prostate, lung, spleen, ovary, testis kidney, placenta, blood and liver
Swiss-Prot Key

 

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